Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG
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منابع مشابه
Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG.
The erythrocyte Rh-associated glycoprotein (RhAG) was recently found to mediate transport of ammonia/ammonium when expressed in Xenopus laevis oocytes and yeast Saccharomyces cerevisiae. Nonerythroid homologs, RhBG and RhCG, are expressed in the mammalian kidney connecting segment and the collecting duct, major sites of urinary ammonia secretion. This study characterizes the transport propertie...
متن کاملAmmonia transport in the kidney by Rhesus glycoproteins.
Renal ammonia metabolism is a fundamental element of acid-base homeostasis, comprising a major component of both basal and physiologically altered renal net acid excretion. Over the past several years, a fundamental change in our understanding of the mechanisms of renal epithelial cell ammonia transport has occurred, replacing the previous model which was based upon diffusion equilibrium for NH...
متن کاملRhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels
Rhesus glycoprotein homologs RhAG, RhBG, and RhCG comprise a recently identified branch of the Mep/Amt ammonia transporter family. Animal studies have shown that RhBG and RhCG are present in the kidney distal tubules. Studies in mouse and rat tissue suggest a basolateral localization for RhBG in cells of the distal tubules including the alpha-intercalated cells (alpha-IC), but no localization o...
متن کاملRhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron.
Two nonerythroid homologs of the blood group Rh proteins, RhCG and RhBG, which share homologies with specific ammonia transporters in primitive organisms and plants, could represent members of a new family of proteins involved in ammonia transport in the mammalian kidney. Consistent with this hypothesis, the expression of RhCG was recently reported at the apical pole of all connecting tubule (C...
متن کاملExpression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract.
Ammonia metabolism is important in multiple aspects of gastrointestinal physiology, but the mechanisms of ammonia transport in the gastrointestinal tract remain incompletely defined. The present study examines expression of the ammonia transporter family members Rh B glycoprotein (RhBG) and Rh C glycoprotein (RhCG) in the mouse gastrointestinal tract. Real-time RT-PCR amplification and immunobl...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2006
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00147.2005